Aprotinin may inhibit virus replications by stopping SARS-CoV-2 entry into host cells


A scientific examine from Spain lately confirmed laboratory experiments made by researchers of Goethe College Frankfurt and College of Kent who confirmed that the protease inhibitor aprotinin prevented cells to be contaminated by SARS-CoV2. The authors of the scientific examine report that sufferers receiving an aprotinin aerosol might be discharged from hospital considerably earlier.

SARS-CoV-2, the coronavirus that causes COVID-19, wants its spike proteins to dock onto proteins (ACE receptors) on the floor of the host cells. Earlier than this docking is feasible, elements of the spike protein must be cleaved by host cell’s enzymes referred to as proteases. In 2020, a scientific staff led by Professor Jindrich Cinatl (Goethe College Frankfurt, Germany), Professor Martin Michaelis and Professor Mark Wass (each College of Kent, UK), carried out cell tradition experiments and located that aprotinin, a protease inhibitor, may inhibit virus replications by stopping SARS-CoV-2 entry into host cells.

In a newer examine, the analysis consortium additional confirmed that aprotinin can also be efficient in opposition to the Delta and Omicron variants.

Now, a Spanish analysis consortium has printed the findings of a section III scientific examine investigating the usage of an aprotinin aerosol in COVID-19 sufferers. Amongst different enhancements, aprotinin therapy lowered the size of hospital stays by 5 days.

This exhibits how scientific collaborations work even with no direct relationship between researchers. I’m very glad that our cell tradition examine impressed this profitable scientific trial”.

Professor Jindrich Cinatl, Goethe College Frankfurt

Professor Martin Michaelis, College of Kent, stated: “Our cell tradition information appeared very convincing. It’s thrilling that aprotinin has now additionally been proven to be efficient in opposition to COVID-19 in sufferers.”


Journal reference:

Redondo-Calvo, F.J., et al. (2022) Aprotinin therapy in opposition to SARS-CoV-2: A randomized section III examine to judge the protection and efficacy of a pan-protease inhibitor for reasonable COVID-19. European Journal of Scientific Investigation. doi.org/10.1111/eci.13776.

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